Study of thyroid hormones and TSH levels in patients with hypothyroidism in Karachi.

Sixty six clinically proven hypothyroid subjects were studied using radioimmunoassay techniques for estimation of serum thyroid hormones and pituitary TSH concentrations. The mean level for serum TSH was significantly elevated while the mean levels for serum T4, 13 and Free T4 were significantly low. A significant positive correlation was found between 14 and T3 and between T4 and FTI. Serum TSH was found to have a significant negative correlation with FTI. There was no significant difference in the mean of various hormones between the males and females. Serum TSH was considered to be the most diagnosis of hypothyroidism (JPMA 37:39 , 1987).